補體系統(tǒng)-藥物開發(fā)和臨床研究熱點

補體系統(tǒng)是由35種廣泛存在于血清、組織液和細(xì)胞膜具有酶活性的蛋白質(zhì)組成的反應(yīng)系統(tǒng)。補體激活有三種途徑：1)經(jīng)典途徑2）旁路途徑3）凝集素反應(yīng)/MBL途徑。補體系統(tǒng)可通過這3條既相對獨立又相互聯(lián)系的途徑被激活，從而發(fā)揮調(diào)理吞噬、裂解細(xì)胞、介導(dǎo)炎癥、免疫調(diào)節(jié)和清除免疫復(fù)合物等多種生物學(xué)效應(yīng)，包括增強吞噬作用，增強吞噬細(xì)胞的趨化性；增加血管的通透性；中和病毒；細(xì)胞溶解作用；免疫反應(yīng)的調(diào)節(jié)作用等。補體系統(tǒng)在抗感染和自身免疫及其他疾病的發(fā)展過程中發(fā)揮重要作用。

Euro Diagnostica補體功能檢測試劑盒優(yōu)勢

1)ELISA檢測方法-三種激活途徑，相同的檢測程序。

2)2005年上市，穩(wěn)定的檢測系統(tǒng)。

3）反映真實的體內(nèi)補體水平。

4）3小時內(nèi)出結(jié)果，快速、準(zhǔn)確。

5）靈活性強-可以適應(yīng)個性的化操作流程。

6）適合自動化檢測系統(tǒng)檢測（Dynex, DS2,DSX）

7) 與溶血試驗（CH50, APH50）檢測結(jié)果一致。

8）性能穩(wěn)定，文獻引用廣

9）CE認(rèn)證，可同時用于臨床和科研檢測。

Euro Diagnostica試劑盒應(yīng)用實例:

1）藥物開發(fā)-補體靶向治療

研究表明,炎性疾病的發(fā)生、發(fā)展同補體的活化有關(guān)。因此,如何干擾和抑制補體活化產(chǎn)生的有害作用,成為藥理學(xué)研究的焦點之一，Euro Diagnostica試劑盒用于評估補體靶向治療效果（參考文獻4-8）。

2）臨床研究-補體功能/活性監(jiān)測

補體功能的評估在補體相關(guān)疾病的發(fā)生和治療中具有重要意義。文獻5-9 用Euro Diagnostica試劑盒監(jiān)測補體疾病治療中補體水平。

3）補體脫靶反應(yīng)

在某些情況下，補體激活可引起嚴(yán)重反應(yīng)，比如候選藥物的脫靶反應(yīng)，抗體依賴的補體激活，移植排斥反應(yīng)。（（參考文獻12-13）。）

訂購信息

應(yīng)用文獻：

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4.Hill A et al. A Subcutaneously Administered Investigational RNAi Therapeutic (ALN-CC5) Targeting Complement C5 for Treatment of PNH and Complement-Mediated Diseases: Interim Phase 1 Study Results. Abstract 2413 ;58th ASH Annual Meeting 2015

5. Jore MM et al. Structural basis for therapeutic inhibition of complement C5. Nature Structural & Molecular Biology 2016: doi:10.1038/nsmb.3196

6. Würzner R et al. Assessment of complement activity by ELISA. Abstract #41 16th Biennial Meeting of the European Society for Immunodeficiencies, ESID 2014

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complement system activity of the newborn. Immunobiology 2015; 220:452–459

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