中文字幕乱码亚洲中文在线-国产亚洲99久久精品熟女av-国产av性感美女久久久-这里有好吊妞精彩视频

18611095289

down

資料下載

當(dāng)前位置:首頁資料下載CTX-I ELISA Kit I型膠原C末端肽ELSIA試劑盒說明書

CTX-I ELISA Kit I型膠原C末端肽ELSIA試劑盒說明書

發(fā)布時(shí)間:2023/8/30點(diǎn)擊次數(shù):324

Type I Collagen C-telopeptide, CTX-I, Assay Kit

Catalog # 6033


INTRODUCTION

Collagen is the most abundant protein in the mammalian body and lends structural integrity to tissues as the primary component of the extracellular matrix (1). Type I collagen is the main component of bone, tendon, skin, and other tissues (2). In fact, type I collagen makes up 20% of bones by mass, which accounts for more than 90% of the organic components. As a result, degradation products of type I collagen can be detected in serum and urine in stages of bone loss or metabolism and can be potential markers of bone metabolism (3).

Proteinases mediate resorption of type I collagen from bone and generate specific peptide fragments of degraded collagen. For example, matrix metalloproteinases (MMPs) exclusively produce C-terminal degraded fragments (ICTP) from type I collagen, while cathepsin K produces-I fragments from the C-terminus and NTX-I fragments from the N-terminus of type I collagen (4). Because the proteinase activities differ among diseases and degraded fragments reflect the metabolism of type I collagen, immunoassays have been developed to monitor

the levels of these degraded fragments in biological fluids (5). Patients with osteoporosis display reduced bone mass. During disease progression, degraded peptides of type I collagen are observed

in serum as well as urine. Therefore, ICTP and NTX-I have been used as markers of osteoporosis (6-8). In addition, it was reported that CTX-I levels in urine are correlated with disease activity of osteoarthritis (9). Furthermore, cancers which metastasize to bone can affect the metabolism of type I collagen. Serum CTX-I levels correlate with prognosis of these cancers, especially prostate, lung, breast, and urinary

bladder cancers 

Thus, degraded type I collagen fragments are very useful tools for evaluating disease not only in humans, but also in mice, leading to the development of many mouse disease models for cancer, osteoporosis, osteoarthritis, and rheumatoid arthritis. Chondrex, Inc. has developed a CTX-I detection ELISA kit for mouse and human using a competitive assay system with a monoclonal antibody which recognizes conserved

peptide sequences in mouse and human .


文件下載    

服務(wù)熱線
18611095289

掃碼加微信

国产又大又硬又粗又湿| 最新国产欧美精品91| 日韩人妻一区二区欧美| 欧美有码黄片免费在线视频| 国产福利一区二区三区四区| 国产又粗又猛又黄又爽视频免费| 在线播放欧美精品一区| 亚洲熟女乱色一区二区三区| 国产午夜免费在线视频| 国产高清一区二区不卡| 亚洲成人免费天堂诱惑| 熟女乱一区二区三区丝袜| 国产精品午夜一区二区三区 | 国产一区二区不卡在线视频| 国产内射在线激情一区| 日本成人三级在线播放| 日韩成人动作片在线观看| 一区二区三区在线不卡免费| 日韩欧美国产亚洲一区| 国产又爽又猛又粗又色对黄| 日韩人妻精品免费一区二区三区| 免费观看日韩一级黄色大片| 欧美加勒比一区二区三区| 九九热精品视频免费观看| 国内九一激情白浆发布| 免费在线成人午夜视频| 国产成人精品一区在线观看| 日韩一级免费中文字幕视频| 好吊妞视频只有这里有精品| 视频在线免费观看你懂的| 欧美日韩国产精品第五页| 久热香蕉精品视频在线播放| 国产无摭挡又爽又色又刺激| 在线观看那种视频你懂的| 人妻少妇系列中文字幕| 一区中文字幕人妻少妇| 国产一区国产二区在线视频| 日本成人三级在线播放 | 日本办公室三级在线观看| 色好吊视频这里只有精| 99久久国产亚洲综合精品|