中文字幕乱码亚洲中文在线-国产亚洲99久久精品熟女av-国产av性感美女久久久-这里有好吊妞精彩视频

18611095289

down

資料下載

當(dāng)前位置:首頁資料下載Human Anti Scl-70 IgG ELISA kit 試劑盒說明書

Human Anti Scl-70 IgG ELISA kit 試劑盒說明書

發(fā)布時(shí)間:2023/11/7點(diǎn)擊次數(shù):282

Human Anti Scl-70 IgG ELISA KIT

Cat # 3300-140-SCG

Intended Use:

ADI's Anti-Scl-70 is an indirect solid phase enzyme immunoassay (ELISA) for thequantitative measurement of IgG class autoantibodies against Scl-70 in humanserum or plasma. The kit is intended for in vitro research use only (RUO) as anaid in the diagnosis of scleroderma.

INTRODUCTION

Rheumatoid autoimmune diseases are often associated with theoccurrence of autoanti-bodies against several nuclear or cytoplasmicantigens. Today the best investigated immunoreactive antigens aredouble-stranded DNA (dsDNA), single stranded DNA (ssDNA), Sm(Smith), sn-RNP (small nuclear ribonucleoprotein particles), the complexRNP/Sm which is stabilized by ribonuleic acid as well as SS-A (Ro) andSS-B (La). The antigen Scl 70, a 70 kD molecular weight protein, alsoknown as DNA-topoisomerase-1, is associated with scleroderma. AntiScl-70 antibodies (also called anti-topoisomerase I) is a type of anti-nuclear autoantibody seen mainly indiffuse systemic scleroderma, but is also seen the more limited form of systemic scleroderma calledCREST syndrome. Anti Scl-70 antibodies are associated with more severe scleroderma disease.Today the best investigated immunoreactive antigens are double-stranded DNA (dsDNA), singlestranded DNA (ssDNA), Sm (Smith), sn-RNP (small nuclear ribonucleoprotein particles), the complexRNP/Sm which is stabilized by ribonuleic acid as well as SS-A (Ro) and SS-B (La). The antigen Scl 70,a 70 kD molecular weight protein, also known as DNA-topoisomerase-1, is associated with scleroderma.In rheumatoid autoimmune diseases various profiles of autoantibodies to these antigens can bedetected. In a high incidence they are related to active and inactive systemic Lupus erythrematodes,mixed connective tissue diseases (Sharp Syndrome), rheumatoid arthritis, Sj?gren-Syndrome,Scleroderma, photosensitve dermatitis and drug-induced lupus. In Lupus patients typically anti-dsDNAantibodies can be detected. Patients without these antibodies very often show anti-ssDNA antibodies and anti-SS-A and anti-SS-B are present. A strong correlation between antibody concentration andseverety of the disease has been observed with higher antibody concentrations in active phases of thedisease. Thus quantitation is more informative compared to simple titering by immunoflourescence. Mostof these parameters are not specific for just one disease but they occur in various combinations. Thepattern of different antibody combinations and their concentration together with the whole clinical pictureof the patient are helpful diagnostic tools in the assessment of rheumatoid autoimmune diseases. Anti- Scl-70 is found in ~75% patients with the diffuse progressive form of scleroderma. The presence of anti- Scl-70 seems to exclude the presence of anti-centromere antibody, which is a marker for a subset ofpatients with scleroderma known as CREST (calcinosis, sclerodactyly, and telangiectasia) syndrome.

SPECIFICITY:

The microplate is coated with Scl-70 antigen highly purified by affinitychromatography. The Anti-Scl-70 test kit is specific only forautoantibodies directed to Scl-70. No cross reactivity to the other ENA- antigens have been observed.

Sensitivity:

The lower detection limit for Anti-Scl-70 has been determined at 1.0U/ml.

Species Reactivity:

This kit is designed to test human samples. It detects IgG class of anti- Scl70 antibodies with no or minimal detection of IgG, IgA or IgEantibodies.ADI has separate kits to detect slc70 antibodies in monkey, mouse or ratsamples.



文件下載    

服務(wù)熱線
18611095289

掃碼加微信

亚洲精品国产主播一区| 亚洲午夜福利不卡片在线| 欧美自拍偷自拍亚洲精品| 午夜成年人黄片免费观看| 樱井知香黑人一区二区| 欧美乱妇日本乱码特黄大片| 欧美精品久久男人的天堂| 高清亚洲精品中文字幕乱码| 加勒比系列一区二区在线观看| 中文字幕人妻综合一区二区| 亚洲男人的天堂就去爱| 亚洲精品国产福利在线| 亚洲三级视频在线观看免费| 国产在线不卡中文字幕| 日本不卡一区视频欧美| 国产一区二区三区午夜精品| 成人精品国产亚洲av久久| 国产欧美日韩精品成人专区| 国内午夜精品视频在线观看| 91久久精品中文内射| 日韩精品视频一二三区| 伊人久久五月天综合网| 日本丰满大奶熟女一区二区| 亚洲精品中文字幕一二三| 久久成人国产欧美精品一区二区 | 日韩人妻av中文字幕| 老司机精品视频在线免费| 俄罗斯胖女人性生活视频| 又色又爽又无遮挡的视频 | 欧美日韩一区二区午夜| 亚洲欧美日本视频一区二区| 天堂网中文字幕在线观看| 色小姐干香蕉在线综合网| 欧美一区二区三区视频区| 久久天堂夜夜一本婷婷| 丁香七月啪啪激情综合| 爱在午夜降临前在线观看| 五月婷日韩中文字幕四虎| 日韩精品成区中文字幕| 爱在午夜降临前在线观看| 国产精品久久精品国产|